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Metalation-alkylation of O-trimethylsilyl formyltrimethylsilane cyanohydrin in the synthesis of oxazoles

โœ Scribed by Cunico, Robert F.; Kuan, Chia P.


Book ID
126018171
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
321 KB
Volume
57
Category
Article
ISSN
0022-3263

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Efficient Williamson type O-alkylation of alcohols was developed using cesium bases in the presence of tetrabutylanmaonium iodide (TBAI) and molecular sieves. Various substrates including unreactive primary and secondary alcohols were converted smoothly to the corresponding ethers. Electrophiles use