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Cesium promoted O-alkylation of alcohols for the efficient ether synthesis

โœ Scribed by Eric E. Dueno; Feixia Chu; Seok-In Kim; Kyung Woon Jung

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
256 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Efficient Williamson type O-alkylation of alcohols was developed using cesium bases in the presence of tetrabutylanmaonium iodide (TBAI) and molecular sieves. Various substrates including unreactive primary and secondary alcohols were converted smoothly to the corresponding ethers. Electrophiles used herein encompass primary bromides and reactive halides such as benzyl bromide and MPMCI.

๐Ÿ“œ SIMILAR VOLUMES

Cs2CO3 promoted O-alkylation of alcohols
Cs2CO3 promoted O-alkylation of alcohols for the preparation of mixed alkyl carbonates
โœ Feixia Chu; Eric E. Dueno; Kyung Woon Jung ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 231 KB

The presence of cesium carbonate and tetrabutylammonium iodide (TBAI) facilitated efficient O-alkylation of alcohols with alkyl halides, giving rise to the exclusive formation of mixed alkyl carbonates, The cesium effect was also examined comparatively with other alkali carbonates.

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