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Metal ion catalysis in the Tetrahymena ribozyme reaction

โœ Scribed by Piccirilli, Joseph A.; Vyle, Joseph S.; Caruthers, Marvin H.; Cech, Thomas R.


Book ID
109782858
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
488 KB
Volume
361
Category
Article
ISSN
0028-0836

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Inversion of configuration at phosphorus during ribozyme-catalyzed cleavage of RNA is usually considered unequivocal proof of in-line attack, but the relevant pseudorotation diagram for formation of the 2('),3(')-cyclic phosphate shows that inversion is not inconsistent with adjacent attack as long