Solid phase synthesis of oligonucleotide
โ
Richard Cosstick; Joseph S. Vyle
๐
Article
๐
1989
๐
Elsevier Science
๐
French
โ 254 KB
Summarv-A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate. Polynucleotide analogues conta