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Metal Complexes of Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors

โœ Scribed by Joaquin Borras; Gloria Alzuet; Sacramento Ferrer; Claudiu T. Supuran

Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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Complexes of several 1,3,4-thiadiazole-2-sulfonamide derivatives possessing strong carbonic anhydrase (CA) inhibitory properties with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin were obtained and characterized. Although the investigated CA inhibitors possessed very powerful inhibitory prop

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In order to find novel active compounds, complexes such as (I)-(III) are prepared. Whereas the parent sulfonamide shows no topical pressure-lowering effects in rabbits in a 2% solution the compounds (I) and (II) are more active than dorzolamide and thus are basis for a new generation of antiglaucoma