ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 52. Metal Complexes of Heterocyclic Sulfonamides: A New Class of Strong Topical Intraocular Pressure-Lowering Agents in Rabbits.

✍ Scribed by C. T. SUPURAN; F. MINCIONE; A. SCOZZAFAVA; F. BRIGANTI; G. MINCIONE; M. A. ILIES

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199837153

✦ Synopsis

In order to find novel active compounds, complexes such as (I)-(III) are prepared. Whereas the parent sulfonamide shows no topical pressure-lowering effects in rabbits in a 2% solution the compounds (I) and (II) are more active than dorzolamide and thus are basis for a new generation of antiglaucoma drugs. -(SUPURAN, C. T.;