✦ LIBER ✦

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 70. Synthesis and Ocular Pharmacology of a New Class of Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Nicotinic Acid and Aromatic/Heterocyclic Sulfonamides

✍ Scribed by Claudiu T. Supuran; Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Fabrizio Briganti; Giovanna Mincione

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 31
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200006134

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Carbonic Anhydrase

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 52. Metal Complexes of Heterocyclic Sulfonamides: A New Class of Strong Topical Intraocular Pressure-Lowering Agents in Rabbits.

✍ C. T. SUPURAN; F. MINCIONE; A. SCOZZAFAVA; F. BRIGANTI; G. MINCIONE; M. A. ILIES 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB

In order to find novel active compounds, complexes such as (I)-(III) are prepared. Whereas the parent sulfonamide shows no topical pressure-lowering effects in rabbits in a 2% solution the compounds (I) and (II) are more active than dorzolamide and thus are basis for a new generation of antiglaucoma