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Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents

โœ Scribed by Maestrelli, Francesca (author);Mura, Paola (author);Casini, Angela (author);Mincione, Francesco (author);Scozzafava, Andrea (author);Supuran, Claudiu T. (author)


Publisher
John Wiley and Sons Inc.
Year
2002
Tongue
English
Weight
119 KB
Volume
91
Category
Article
ISSN
0022-3549

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Cyclodextrin complexes of sulfonamide ca
โœ Maestrelli, Francesca (author);Mura, Paola (author);Casini, Angela (author);Minc ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 119 KB

Complexes of several 1,3,4-thiadiazole-2-sulfonamide derivatives possessing strong carbonic anhydrase (CA) inhibitory properties with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin were obtained and characterized. Although the investigated CA inhibitors possessed very powerful inhibitory prop

ChemInform Abstract: Carbonic Anhydrase
โœ C. T. SUPURAN; F. MINCIONE; A. SCOZZAFAVA; F. BRIGANTI; G. MINCIONE; M. A. ILIES ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

In order to find novel active compounds, complexes such as (I)-(III) are prepared. Whereas the parent sulfonamide shows no topical pressure-lowering effects in rabbits in a 2% solution the compounds (I) and (II) are more active than dorzolamide and thus are basis for a new generation of antiglaucoma