Complexes of several 1,3,4-thiadiazole-2-sulfonamide derivatives possessing strong carbonic anhydrase (CA) inhibitory properties with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin were obtained and characterized. Although the investigated CA inhibitors possessed very powerful inhibitory prop
โฆ LIBER โฆ
Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents
โ Scribed by Maestrelli, Francesca (author);Mura, Paola (author);Casini, Angela (author);Mincione, Francesco (author);Scozzafava, Andrea (author);Supuran, Claudiu T. (author)
- Publisher
- John Wiley and Sons Inc.
- Year
- 2002
- Tongue
- English
- Weight
- 119 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0022-3549
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In order to find novel active compounds, complexes such as (I)-(III) are prepared. Whereas the parent sulfonamide shows no topical pressure-lowering effects in rabbits in a 2% solution the compounds (I) and (II) are more active than dorzolamide and thus are basis for a new generation of antiglaucoma
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