We report studies of the effect of ischemia on the metabolic activity of the intact perfused lung and its restoration after a period of reperfusion. Two groups of rat lungs were studied using hyperpolarized 1β^13^C pyruvate to compare the rate of lactate labeling differing only in the temporal order
Metabolism of isosorbide dinitrate in the isolated perfused rabbit lung
β Scribed by Philip R. Mayer; William C. Lubawy; Patrick J. McNamara; Harry B. Kostenbauder
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 541 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
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A selective and sensitive capillary column gas-liquid chromatographic procedure has been developed for the simultaneous determination of isosorbide dinitrate (ISDN) and its mononitrate metabolites in rabbit blood and tissue homogenates. The method has a limit of detection of O.lng ml-l for ISDN, l n
The effects of acetaminophen on the metabolism of the isolated perfused rat liver were investigated. The following results were obtained: (1) Acetaminophen increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). (2) Oxygen uptake, gluconeogenesis from either pyruvate or
We have studied the action of a series of vasoactive and antispasmodic agents on the intrahepatic vasoconstriction induced by adrenaline in the isolated perfused liver of rabbits. The arterial and portal venous resistance, oxygen consumption, liver weight and bile flow were investigated. The drugs u