Methimazole (MMI) (>0.1 mmol kg(-1), p.o.) given in combination with DL-buthionine sulphoximine (BSO) (3 mmol kg(-1), i.p., 1 h before MMI administration), an inhibitor of glutathione (GSH) synthesis, caused liver injury in mice. The injury was characterized by centrilobular necrosis of hepatocytes
β¦ LIBER β¦
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice
β Scribed by Shinji Shimizu; Ryo Atsumi; Kenichi Itokawa; Masaru Iwasaki; Takanori Aoki; Chiho Ono; Takashi Izumi; Kenichi Sudo; Osamu Okazaki
- Book ID
- 105870784
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 548 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Metabolism-dependent hepatotoxicity of m
β
Tamio Mizutani; Mihoko Murakami; Mutsuko Shirai; Maki Tanaka; Kazuo Nakanishi
π
Article
π
1999
π
John Wiley and Sons
π
English
β 308 KB
π 1 views
Hepatotoxicity of metals in glutathione-
β
Siegers, C.-P.; Sharma, S.C.; Younes, M.
π
Article
π
1986
π
Elsevier Science
π
English
β 389 KB
p-Dichlorobenzene-induced hepatotoxicity
β
Tamio Mizutani; Yoshiko Nakahori; Kei-ichi Yamamoto
π
Article
π
1994
π
Elsevier Science
π
English
β 591 KB
Evidence for the Involvement of N -Methy
β
Mizutani, Tamio; Yoshida, Kaoru; Murakami, Mihoko; Shirai, Mutsuko; Kawazoe, Sad
π
Article
π
2000
π
American Chemical Society
π
English
β 127 KB
Regulation of hepatic glutathione metabo
β
M. Kretzschmar
π
Article
π
1996
π
Elsevier Science
π
English
β 949 KB
Effect of phorone-induced glutathione de
β
C.-P. Siegers; W. Horn; M. Younes
π
Article
π
1985
π
John Wiley and Sons
π
English
β 397 KB
π 1 views
Although the depletion of hepatic glutathione in male rats following treatment with phorone (diisopropylidene acetone) did not affect the xenobiotic-metabolizing microsomal enzyme system, the metabolic elimination of vinylidene chloride (VDC) from the atmosphere of a closed exposure system was inhib