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Regulation of hepatic glutathione metabolism and its role in hepatotoxicity

✍ Scribed by M. Kretzschmar


Book ID
114305692
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
949 KB
Volume
48
Category
Article
ISSN
0940-2993

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Methimazole (MMI) (>0.1 mmol kg(-1), p.o.) given in combination with DL-buthionine sulphoximine (BSO) (3 mmol kg(-1), i.p., 1 h before MMI administration), an inhibitor of glutathione (GSH) synthesis, caused liver injury in mice. The injury was characterized by centrilobular necrosis of hepatocytes