Hepatotoxicity of metals in glutathione-depleted mice
โ Scribed by Siegers, C.-P.; Sharma, S.C.; Younes, M.
- Book ID
- 123183826
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 389 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0378-4274
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๐ SIMILAR VOLUMES
Methimazole (MMI) (>0.1 mmol kg(-1), p.o.) given in combination with DL-buthionine sulphoximine (BSO) (3 mmol kg(-1), i.p., 1 h before MMI administration), an inhibitor of glutathione (GSH) synthesis, caused liver injury in mice. The injury was characterized by centrilobular necrosis of hepatocytes
Experimental models for halothane hepatotoxicity require microsomal enzyme induction by phenobarbital or triiodo-thyronine pretreatment and hypoxic conditions. The role of GSH in the metabolism of halothane, however, is still unclear. We therefore pretreated male rats with phorone to deplete hepatic