Metabolism and pharmacokinetics of 1,3-butadiene
โ Scribed by Linda S. Birnbaum; Douglas A. Keller
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 253 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Metabolism of 1,3-butadiene to 1,2-epoxybutene-3 in rats follows saturation kinetics. Comparative investigation of inhalation pharmacokinetics in mice also revealed a saturation pattern. For both species "linear" pharmacokinetics apply at exposure concentrations below 1000 ppm 1,3-butadiene; saturat
The metabolism of encainide occurs in the liver and is polymorphically distributed according to the same genetic factor that determines the 4-hydroxylation of debrisoquine. Over 90% of patients are extensive metabolizers (EM) in whom the oral bioavailability of encainide is only 30% because of exten