Metabolism of 1,3-butadiene to 1,2-epoxybutene-3 in rats follows saturation kinetics. Comparative investigation of inhalation pharmacokinetics in mice also revealed a saturation pattern. For both species "linear" pharmacokinetics apply at exposure concentrations below 1000 ppm 1,3-butadiene; saturat
Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice
โ Scribed by Matthew W. Himmelstein; Max J. Turner; Bahman Asgharian; James A. Bond
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 317 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0300-483X
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Comparative investigations of inhalation pharmacokinetics of 1,2-epoxybutene-3 (vinyl oxirane, the primary reactive intermediate of butadiene) revealed major differences in metabolism of this compound between rats and mice. Whereas in rats no indication of saturation kinetics of epoxybutene metaboli
Renal, biliary, pulmonary and faecal excretion experiments were carried out with labelled hexachloro-1,3butadiene ([I4C]HCBD) in male Sprague-Dawley rats, given orally (p.0.) and intravenously (i.v.) in doses of 1 and 100 mg kg-' as a solution in polyethylene glycol. The radioactivity excreted over