Metabolic products of microorganisms

✍ Scribed by Heidrun Anke; Hans Zähner; Wilfried A. König

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 400 KB
• Volume: 116
• Category: Article
• ISSN: 0302-8933
• DOI: 10.1007/bf00417848

✦ Synopsis

C l a d o s p o r i n was isolated from the cultures of three species of the genus Eurotium. Cladosporin inhibited the growth of several fungi and at very low c o n c e n t r a t i o n s the growth of Bacillus brevis a n d Clostridium pasteurianum. Bacillus subtilis a n d most other Gram-positive bacteria were not sensitive. G r a m -n e g a t i v e bacteria and yeasts were not affected by c o n c e n t r a t i o n s up to 100 gg/ml. D i m e t h y l cladosporin showed only weak activity against Bacillus brevis with the m i n i m a l inhibitory c o n c e n t r a t i o n s being a 100 times higher than of cladosporin. The i n c o r p o r a t i o n of leucine and uracil into acid insoluble material in Bacillus brevis cells was completely inhibited by c o n c e n t r a t i o n of 0.5 gg/ml cladosporin. The i n c o r p o r a t i o n of t h y m i d i n e was not affected at this concentration.