𝔖 Bobbio Scriptorium
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Metabolic fate of orally administered 2,3,5-triiodobenzoic acid in lactating animals

✍ Scribed by Rodney D. Ice; John E. Christian; Millard P. Plumlee

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
719 KB
Volume
57
Category
Article
ISSN
0022-3549

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✦ Synopsis

The whole body retention, excretion, distribution, thyroid uptake, and metabolism of 2(~311),3r5-triiodobenzoic acid (TI*BA) were studied in goats and a cow. A single oral dose of TIBA exhibited a two-component whole body radioactivity retention curve and was excreted primarily in the urine. TIBA plus nine metabolites, four of which were identified, were found in the urine. The major metabolite was 2,5-diiodobenzoic acid (2,5-DIBA). Trace amounts of 2,3-diiodobenzoic acid (2,3- DIBA), orthoiodobenzoic acid (OIBA), and iodide ion were found. TIBA was metabolized by deiodination. Iodide ion was concentrated in the thyroid and excreted by way of milk and urine.

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