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Urinary 2-ethyl-3-oxohexanoic acid as major metabolite of orally administered 2-ethylhexanoic acid in human

✍ Scribed by Dana Stingel; Peter Feldmeier; Elke Richling; Michael Kempf; Sandra Elss; Samira Labib; Peter Schreier

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 536 KB
Volume: 51
Category: Article
ISSN: 1613-4125
DOI: 10.1002/mnfr.200600136

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✦ Synopsis

Abstract

Human metabolism of 2‐ethylhexanoic acid (2‐EHA), which is a known metabolite of important phthalates, was investigated using 2‐EHA‐contaminated food. The results of our studies reveal that the major catabolic pathway of 2‐EHA in human is β‐oxidation. The dominant final urinary metabolite was identified and quantified as 3‐oxo‐2‐ethylhexanoic acid (3‐oxo‐2‐EHA), but only after immediate methylation of the extract from urine and prior to GC‐MS analysis. Former studies without the precaution of immediate methylation had found 4‐heptanone as the major metabolite, which is obviously an artifact arising from the decarboxylation of 3‐oxo‐2‐EHA.

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