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Metabolic Fate of Glutathione Conjugate of Benzo[a]pyrene-(7R,8S)-diol (9S,10R)-epoxide in Human Liver

โœ Scribed by Sanjay K. Srivastava; Xun Hu; Hong Xia; Sanjay Awasthi; Shantu Amin; Shivendra V. Singh


Book ID
115567887
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
97 KB
Volume
371
Category
Article
ISSN
0003-9861

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โœ Sanjay K. Srivastava; Simon C. Watkins; Erin Schuetz; Shivendra V. Singh ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 277 KB

## Abstract Glutathione (GSH) conjugation of (+)โ€antiโ€benzo[__a__]pyreneโ€7,8โ€diolโ€9,10โ€epoxide [(+)โ€antiโ€BPDE], the activated metabolite of benzo[__a__]pyrene, is believed to be an important mechanism in detoxification of this environmental and dietary carcinogen. Here, we demonstrate that the intr