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Glutathione transferase catalyzed conjugation of benzo[a]pyrene 7,8-diol 9,10-epoxide with glutathione in human skin

✍ Scribed by B. Jernström; L. Dock; M. Hall; B. Mannervik; M.K. Tahir; P.L. Grover


Book ID
113137229
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
616 KB
Volume
70
Category
Article
ISSN
0009-2797

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✍ Sanjay K. Srivastava; Simon C. Watkins; Erin Schuetz; Shivendra V. Singh 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB

## Abstract Glutathione (GSH) conjugation of (+)‐anti‐benzo[__a__]pyrene‐7,8‐diol‐9,10‐epoxide [(+)‐anti‐BPDE], the activated metabolite of benzo[__a__]pyrene, is believed to be an important mechanism in detoxification of this environmental and dietary carcinogen. Here, we demonstrate that the intr