Alkaloids purified from plants provide many pharmacologically active compounds, including leading chemotherapy drugs. As is generally true of secondary metabolites, overall productivity is low, making commercial production expensive. Alternative production methods remain impractical, leaving the pla
Metabolic Engineering of Plants: The Role of Membrane Transport
✍ Scribed by Reinhard Kunze; Wolf B. Frommer; Ulf-Ingo Flügge
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 360 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1096-7176
No coin nor oath required. For personal study only.
✦ Synopsis
As plant cells are highly compartmentalized, the entrance and exit points of metabolic pathways frequently involve membrane passages of solutes. Transport proteins are often located in strategic positions to control whole pathways and have to be considered in the development of metabolic engineering strategies. Here, we discuss examples of pathways (in carbohydrate metabolism, amino acid and secondary compound synthesis, and mineral metabolism) in which membrane transport steps are considered to exert major control and in which transport proteins have been employed to manipulate metabolic fluxes.
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