✦ LIBER ✦

Metabolic Engineering of Plants for Alkaloid Production

✍ Scribed by Erik H. Hughes; Jacqueline V. Shanks

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 145 KB
Volume: 4
Category: Article
ISSN: 1096-7176
DOI: 10.1006/mben.2001.0205

No coin nor oath required. For personal study only.

✦ Synopsis

Alkaloids purified from plants provide many pharmacologically active compounds, including leading chemotherapy drugs. As is generally true of secondary metabolites, overall productivity is low, making commercial production expensive. Alternative production methods remain impractical, leaving the plant as the best source for these valuable chemicals. Recently, significant progress in characterizing the biosynthetic pathways leading to various alkaloids has been made, and a number of relevant genes have been cloned. Metabolic engineering employing such genes provides a promising technology for improved productivity in plant cell cultures, plant tissue cultures, or intact plants. In exploring solutions though, metabolic engineers must be careful to recognize the limitations inherent in designing plant systems.

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