✦ LIBER ✦

Metabolic Activation of the Potent Carcinogen Dibenzo[a,h]anthracene by cDNA-Expressed Human Cytochromes P450

✍ Scribed by Magang Shou; Kristopher W. Krausz; Frank J. Gonzalez; Harry V. Gelboin

Book ID: 115565998
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 164 KB
Volume: 328
Category: Article
ISSN: 0003-9861
DOI: 10.1006/abbi.1996.0161

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Specificity of cDNA-expressed human and

Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene

✍ Magang Shou; Kenneth R. Korzekwa; Kristopher W. Krausz; Jeroen T. M. Buters; Jam 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 913 KB

7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) t o electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of

Stereo-Selective Metabolism of Methadone

Stereo-Selective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation

✍ Yan Chang; Wenfang B. Fang; Shen-Nan Lin; David E. Moody 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB

Metabolic Activation of Pyrolysate Aryla

Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P-448-H Type Cytochrome P-450

✍ Yamazoe, Yasushi ;Abu-Zeid, Medhat ;Yamauchi, Kiyomi ;Kato, Ryuichi 📂 Article 📅 1988 🏛 Wiley (Blackwell Publishing) 🌐 English ⚖ 483 KB

The Kinetics of Aflatoxin B1Oxidation by

The Kinetics of Aflatoxin B1Oxidation by Human cDNA-Expressed and Human Liver Microsomal Cytochromes P450 1A2 and 3A4

✍ Evan P. Gallagher; Kent L. Kunze; Patricia L. Stapleton; David L. Eaton 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 212 KB

Characterisation of the xenobiotic-metab

Characterisation of the xenobiotic-metabolizing Cytochrome P450 expression pattern in human lung tissue by immunochemical and activity determination

✍ Ulrike Bernauer; Barbara Heinrich-Hirsch; Mario Tönnies; Wolski Peter-Matthias; 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 289 KB

Stable expression of human cytochrome P4

Stable expression of human cytochrome P450IA2 cDNA in a human lymphoblastoid cell line: Role of the enzyme in the metabolic activation of aflatoxin B1

✍ Charles L. Crespi; Dorothy T. Steimel; Toshifumi Aoyama; Harry V. Gelboin; Frank 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 367 KB

## Abstract A human lymphoblastoid cell line stably expressing a human cytochrome P4501A2 cDNA was developed. This recombinant cell line displayed P4501A2 protein and estradiol2‐hydroxylase activity, neither of which was detected in the parental cell line. The recombinant cell line was also approxi