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Stereo-Selective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation

โœ Scribed by Yan Chang; Wenfang B. Fang; Shen-Nan Lin; David E. Moody

Book ID
111316871
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
237 KB
Volume
108
Category
Article
ISSN
1742-7835

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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th