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Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1

✍ Scribed by Tsutomu Shimada; Yoshiaki Fujii-Kuriyama


Book ID
108582379
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
279 KB
Volume
95
Category
Article
ISSN
1347-9032

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## Abstract Metabolites of the human carcinogen 4‐aminobiphenyl (4‐ABP) form hemoglobin (Hb) adducts, which represent a useful biomarker for exposure. However, not every individual responds to a similar degree to 4‐ABP exposure, and variations in 4‐ABP‐Hb adduct formation might be explained by gene