Molecular characterization of cytochrome P450 genes in the polycyclic aromatic hydrocarbon degradingMycobacterium vanbaaleniiPYR-1
β Scribed by Barbara Brezna; Ohgew Kweon; Robin L. Stingley; James P. Freeman; Ashraf A. Khan; Bystrik Polek; Richard C. Jones; Carl E. Cerniglia
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 58 KB
- Volume
- 72
- Category
- Article
- ISSN
- 1432-0614
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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione sβtransferase M1 (GSTM1). PAHβDNA a
PM3 molecular orbital calculations were carried out to estimate CH bond dissociation energies of 13 polycyclic aromatic hydrocarbon (PAH) molecular cations. The dissociation energy of a CH bond turned out to be almost independent of the size of the molecular cation and the environment in the cation.