𝔖 Bobbio Scriptorium
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The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P-450; the past is prologue

✍ Scribed by P. L. Iversen; R. N. Hines; Edward Bresnick


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
577 KB
Volume
4
Category
Article
ISSN
0265-9247

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✦ Synopsis


Tyrosine phosphorylation within the aminoterminal domain of pp60c-src molecules associated with polyoma virus middle tumor antigen. Proc. Natl. Acad. Sci. USA 82,45684572.


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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a