Metabolic activation and reactivity of chemical carcinogens
β Scribed by James A. Miller; Elizabeth C. Miller
- Book ID
- 113190504
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 122 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0027-5107
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π SIMILAR VOLUMES
A great deal of effort has gone into research on the mechanisms of action of chemical carcinogens. The action of the host on the carcinogen represents one approach--to determine what metabolic products may be involved. Study of the action of the carcinogen on the host requires a thorough comparison
## Abstract A free radical was produced enzymatically by incubating benzo(a)pyrene with liver microsomes. This radical, identified as the 6βoxybenzo(a) pyrene radical, was sufficiently reactive to bind covalently with nucleic acid bases. Similar reactive free radicals were produced enzymatically fr