Cell and species differences in metabolic activation of chemical carcinogens
β Scribed by I.C. Hsu; C.C. Harris; M.M. Lipsky; S. Snyder; B.F. Trump
- Book ID
- 113193085
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 534 KB
- Volume
- 177
- Category
- Article
- ISSN
- 0027-5107
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A great deal of effort has gone into research on the mechanisms of action of chemical carcinogens. The action of the host on the carcinogen represents one approach--to determine what metabolic products may be involved. Study of the action of the carcinogen on the host requires a thorough comparison
## Abstract The metabolism of chemical carcinogens has been studied in cultured human bronchus, colon, duodenum, pancreatic duct, and esophagus. Metabolite patterns and carcinogenβDNA adducts are generally qualitatively similar among animal species, individuals within a species, and tissues within