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Metabolic activation of chemical carcinogens and binding of metabolites with nucleic acid bases

✍ Scribed by Chikayoshi Nagata; Masahiko Kodama; Teruyuki Kimura; Tamié Yamaguchi

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
585 KB
Volume
16
Category
Article
ISSN
0020-7608

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✦ Synopsis

Abstract

A free radical was produced enzymatically by incubating benzo(a)pyrene with liver microsomes. This radical, identified as the 6‐oxybenzo(a) pyrene radical, was sufficiently reactive to bind covalently with nucleic acid bases. Similar reactive free radicals were produced enzymatically from anthanthrene and 10‐aza‐benzo(a)pyrene, which are carcinogenic in spite of lacking so‐called “bay regions.” Hepatocarcinogens such as 3′‐methyl‐4‐dimethylaminoazobenzene and related compounds, naphthylamines, and 2‐acetylaminofluorene yield free radicals after being incubated with liver microsomes. Thus, various kinds of chemical carcinogens are found to be converted to free radicals, suggesting causal significance for the formation of free radicals in chemical carcinogenesis.

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