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Metabolic actions of insulin-like growth factor-I in cultured hepatocytes from adult rats

✍ Scribed by Dr. Heinz Hartmann; Frank Schmitz; Bruno Christ; Kurt Jungermann; Werner Creutzfeldt

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
504 KB
Volume
12
Category
Article
ISSN
0270-9139

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✦ Synopsis

Republic of Germany

* Insulinlike growth factor-I (IGF-I) is of critical importance in the regulation of tissue growth and cellular differentiation (1, 2). In addition to its growthpromoting effects, a rapid insulin-like metabolic activity (e.g., hypoglycemia after intravenous injection) has been demonstrated in humans and rats (3, 4). Short-term effects of IGF-I on liver metabolism were suggested by studies of glycogen synthesis and amino acid uptake in fetal rat hepatocytes (5) and in a human hepatoma cell

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