Monoamine oxidases catalyse the oxidative degradation of biogenic amines including neurotransmitters such as noradrenaline, dopamine, and 5-hydroxytryptamine (5-HT). Three groups have reported positive associations of the monoamine oxidase A (MAOA) gene with bipolar affective disorder although other
Meta-study on association between the monoamine oxidase A gene (MAOA) and schizophrenia
β Scribed by Dawei Li; Lin He
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 125 KB
- Volume
- 147B
- Category
- Article
- ISSN
- 1552-4841
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## Abstract Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. To study a possible role of the __MAOA__
~ W e have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM 111-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA a dinucleotide repeat in intron 2, a VN