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Menkes Disease: A Biochemical Abnormality in Cultured Human Fibroblasts

✍ Scribed by Thomas J. Goka, Roger E. Stevenson, Patrick M. Hefferan and R. Rodney Howell

Book ID
123653582
Publisher
National Academy of Sciences
Year
1976
Tongue
English
Weight
711 KB
Volume
73
Category
Article
ISSN
0027-8424

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Synthesis of a metallothionein-like prot
Synthesis of a metallothionein-like protein in cultured human skin fibroblasts: Relation to abnormal copper distribution in Menkes' disease
✍ Dr. Roland F. Bonewitz Jr.; R. Rodney Howell πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 754 KB

## Abstract A metallothionein‐like protein (MTP) is synthesized in normal diploid human skin fibroblasts cultured in Zn‐ or Cu‐supplemented medium. Synthesis of MTP is not detected in cells cultured without metal supplementation of complete tissue‐culture medium. Cultured fibroblasts from patients