𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Memory, anticonvulsant drugs and seizures

✍ Scribed by Michael R. Trimble; Pamela J. Thompson


Book ID
114781163
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
785 KB
Volume
64
Category
Article
ISSN
0001-6314

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Effects of anticonvulsant drugs on 4-ami
✍ Shun-ichi Yamaguchi; Michael A. Rogawski πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 645 KB

The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s