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Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs

✍ Scribed by Mark H. Coleman; Shun-ichi Yamaguchi; Michael A. Rogawski

Book ID
115802708
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
498 KB
Volume
575
Category
Article
ISSN
0006-8993

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✍ Shun-ichi Yamaguchi; Michael A. Rogawski πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 645 KB

The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s