𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Further studies on anticonvulsant drugs and seizures

✍ Scribed by Pamela J. Thompson; Michael R. Trimble


Book ID
114781165
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
466 KB
Volume
64
Category
Article
ISSN
0001-6314

No coin nor oath required. For personal study only.


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The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s