Membranes and Cell Signaling

✍ Scribed by E. Edward Bittar and Neville Bittar (Eds.)

Publisher: Elsevier Science
Year: 1997
Tongue: English
Leaves: 359
Series: Principles of Medical Biology 7
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be. We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.

✦ Table of Contents

Content:
List of contributors
Pages xi-xv

Preface
Pages xvii-xviii
E. Edward Bittar, Neville Bittar

Chapter 1 Model membrane systems Original Research Article
Pages 1-17
Thomas D. Madden

Chapter 2 Lipid-bilayer heterogeneity Original Research Article
Pages 19-38
Kent Jørgensen, John Hjort Ipsen, Ole G. Mouritsen

Chapter 3 Lipid-protein interactions in biological membranes Original Research Article
Pages 39-66
Paul Burn, Bruno H. Dalle Carbonare

Chapter 4 Lipid modifications of proteins and their relevance to protein targeting Original Research Article
Pages 67-91
Philippe Zlatkine, Anthony I. Magee

Chapter 5 Influence of diet fat on membranes Original Research Article
Pages 93-119
Michael Thomas Clandinin

Chapter 6 Membrane fusion and exocytosis Original Research Article
Pages 121-141
Carl E. Creutz

Chapter 7 Endocytosis Original Research Article
Pages 143-169
Thomas Wileman

Chapter 8 Eukaryotic signal sequences Original Research Article
Pages 171-183
Mark O. Lively

Chapter 9 Proteolysis in protein import and export: The structure and function of signal peptidases Original Research Article
Pages 185-204
Matthias Müller

Chapter 10 The sorting of proteins Original Research Article
Pages 205-227
Stephen S. Rothman

Chapter 11 Molecular genetics and evolution of voltage-gated ion channels Original Research Article
Pages 229-244
Lawrence Salkoff, Timothy Jegla

Chapter 12 Molecular biology of voltage-gated ionic channels: Structure-function relationships Original Research Article
Pages 245-305
Dalia Gordon

Chapter 13 Ligand-gated ion channels in vertebrates Original Research Article
Pages 307-340
Nomi Eshhar

Contents (Volume 7A)
Pages ix-x

List of contributors
Pages xi-xv

Preface
Pages xvii-xviii
E. Edward Bittar, Neville Bittar

Chapter 14 Mechano-sensitive ion channels Original Research Article
Pages 341-354
Catherine E. Morris

Chapter 15 Patch clamping methods and analysis of ion channels Original Research Article
Pages 355-375
N.B. Standen, N.W. Davies, P.R. Stanfield

Chapter 16 Functional expression of ionic channels and membrane transporters in Xenopus oocytes Original Research Article
Pages 377-385
Simon M. Jarvis

Chapter 17 The plasma membrane as a transducer and amplifier Original Research Article
Pages 387-419
David L. Severson, Morley D. Hollenberg

Chapter 18 G-protein coupled receptors and hormone secretion Original Research Article
Pages 421-450
G.J. Law, M. Rupnik, R. Zorec, P.M. Lledo, W.T. Mason

Chapter 19 The role of ras in signal transduction Original Research Article
Pages 451-468
Alan Hall

Chapter 20 The polyphosphoinositide signaling system Original Research Article
Pages 469-486
Ata A. Abdel-Latif

Chapter 21 Lipids as second messengers Original Research Article
Pages 487-513
Yusuf A. Hannun

Chapter 22 The role of intracellular calcium as a regulatory signal Original Research Article
Pages 515-530
John R. Dedman, Marcia A. Kaetzel

Chapter 23 Guanylyl cyclases as signal transducing enzymes Original Research Article
Pages 531-540
Doris Koesling

Chapter 24 Stimulus-response coupling in secretory cells Original Research Article
Pages 541-572
Ole H. Petersen

Chapter 25 Extracellular matrix adhesion: Biological, molecular, and pathogenic mechanisms Original Research Article
Pages 573-607
Lloyd A. Culp, Kathleen L. O'Connor, Roseanna Lechner

Chapter 26 Intercellular communication: The roles and structure of gap junctions Original Research Article
Pages 609-628
W. Howard Evans

Index
Pages 629-637

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