Cell Structure and Signaling

✍ Scribed by E. Edward Bittar (Eds.)

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Leaves: 257
• Series: Advances in Molecular and Cell Biology 24
• Edition: 1
• Category: Library

✦ Synopsis

In the past approximately quarter of a century, science has made significant progress in elucidating the skeletal elements of the cell, the extracellular matrix, cytoskeleton and nuclear matrix (i.e. the tissue matrix). While we currently know a great deal about some of the elements that comprise these structural systems, we still do not fully understand cellular structures and their relationship to cellular function. The cell is a highly ordered machine in which the skeleton provides the framework on which cellular functions take place. It is now becoming apparent that what were typically considered ''soluble reactions'' are rare, if existent at all. The structural systems contribute more to the cell than a framework for shape, although this is an important function. Cellular shape is reflecting what a cell is, does and will be. One can not inextricably separate cell structure and function, they go hand-in-hand.
Numerous laboratories have contributed to our current understanding of the role of cell structure in cell signaling and we are now at an exciting time in this field. This volume summerizes where investigations into the role of the tissue matrix system in cellular signaling have come and to propose new directions that this research will take in the next several years. This is not meant to be complete, but hopefully will provide the reader with an overview on our current understanding of this field.

✦ Table of Contents

Content:
Edited by
Page iii

Copyright
Page iv

List of Contributors
Pages vii-ix

Preface
Pages xi-xiii
Robert H. Getzenberg

Extracellular Matrix and Nuclear Matrix Interactions May Regulate Apoptosis and Tissue-Specific Gene Expression: A Concept Whose Time has Come Original Research Article
Pages 1-55
Sophie Lelièvre, Valerie M. Weaver, Carolyn A. Larabell, Mina J. Bissell

Role of the Extracellular Matrix and Cytoskeleton in the Regulation of Cyclins, Cyclindependent Kinase Inhibitors, and Anchorage-Dependent Growth Original Research Article
Pages 57-75
Richard K. Assoian, Xiaoyun Zhu, Cabriela E. Davey, Maria Elena Bottazzi

Aptamer Adaptability: Utilizing Tumor Cell Surface Heterogeneity to Self-Select Appropriate Diagnostic and Therapeutic Agents Original Research Article
Pages 77-93
Miguel Garcia Schürmann, Donald S. Coffey

Cytoskeleton-Mediated Aspects of Signal Transduction Original Research Article
Pages 95-123
Raquell M. Holmes, Mary Jo Carabatsos, David F. Albertini

The Role of the Cytoskeleton in Adhesion-Mediated Signaling and Gene Expression Original Research Article
Pages 125-163
Avri Ben-Ze′ev, Alexander D. Bershadsky

Subnuclear Trafficking of Steroid Receptors Original Research Article
Pages 165-183
Donald B. DeFranco, Jimin Liu, Yuting Tang, Jun Yang

The Role of Nuclear Matrix in Tissue-Specific Gene Expression Original Research Article
Pages 185-206
Michael J. Horton, Robert H. Getzeberg

Explaining Aberrations of Cell Structure and Cell Signaling in Cancer Using Complex Adaptive Systems Original Research Article
Pages 207-247
Eric D. Schwab, Kenneth J. Pienta

Index
Pages 249-256