Membrane Dynamics and Calcium Signaling

✍ Scribed by Joachim Krebs

• Publisher: Springer International Publishing
• Year: 2017
• Tongue: English
• Leaves: 409
• Series: Advances in Experimental Medicine and Biology 981
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field.

Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology.

✦ Table of Contents

Front Matter ....Pages i-viii
Front Matter ....Pages 1-1
The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plasma Membrane Microdomains (Joachim Krebs)....Pages 3-21
Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex (Jianping Wu, Nieng Yan, Zhen Yan)....Pages 23-39
Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants (Daniel Khananshvili)....Pages 41-58
Front Matter ....Pages 59-59
The Endoplasmic Reticulum and the Cellular Reticular Network (Luis B. Agellon, Marek Michalak)....Pages 61-76
Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin (Przemek A. Gorski, Delaine K. Ceholski, Howard S. Young)....Pages 77-119
Structural Insights into IP3R Function (Irina I. Serysheva, Mariah R. Baker, Guizhen Fan)....Pages 121-147
IP3 Receptor Properties and Function at Membrane Contact Sites (Gemma Roest, Rita M. La Rovere, Geert Bultynck, Jan B. Parys)....Pages 149-178
Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism (Katrien Willegems, Rouslan G. Efremov)....Pages 179-204
Store-Operated Calcium Entry: An Historical Overview (James W. Putney)....Pages 205-214
From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation (Masahiro Enomoto, Tadateru Nishikawa, Naveed Siddiqui, Steve Chung, Mitsuhiko Ikura, Peter B. Stathopulos)....Pages 215-251
Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1 (Krishna P. Subedi, Hwei Ling Ong, Indu S. Ambudkar)....Pages 253-276
Front Matter ....Pages 277-277
Beyond Intracellular Signaling: The Ins and Outs of Second Messengers Microdomains (Riccardo Filadi, Emy Basso, Konstantinos Lefkimmiatis, Tullio Pozzan)....Pages 279-322
Mitochondrial VDAC, the Na+/Ca2+ Exchanger, and the Ca2+ Uniporter in Ca2+ Dynamics and Signaling (Varda Shoshan-Barmatz, Soumasree De)....Pages 323-347
Front Matter ....Pages 349-349
Annexins: Ca2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment (Carlos Enrich, Carles Rentero, Elsa Meneses-Salas, Francesc Tebar, Thomas Grewal)....Pages 351-385
Front Matter ....Pages 387-387
Ca2+ Signalling and Membrane Dynamics During Cytokinesis in Animal Cells (Sarah E. Webb, Andrew L. Miller)....Pages 389-412

✦ Subjects

Life Sciences; Membrane Biology; Protein-Ligand Interactions; Biological and Medical Physics, Biophysics