Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model
β Scribed by Susan J. Atkinson; Margaret L. Patterson; Michael J. Butler; Gillian Murphy
- Book ID
- 117102776
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 342 KB
- Volume
- 491
- Category
- Article
- ISSN
- 0014-5793
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Recently a novel membrane-type matrix metalloproteinase-1 (MT-MMP-1) was discovered to be a specific activator of progelatinase A, and was correlated with tumor invasion. To the authors' knowledge, no information regarding the expression of MT-MMP-1 has been reported in childhood malignancies. In th
## Abstract Membraneβtype 1 matrix metalloproteinase (MT1βMMP) has been implicated as a physiological activator of progelatinase A (MMPβ2). We previously reported that plasmin treatment of cells results in proMMPβ2 activation and increased type IV collagen degradation. Here, we analyzed the role of