## Abstract The third helix of the homeodomain of the Antennapedia homeoprotein can translocate through the cell membrane into the nucleus and can be used as an intracellular vehicle for the delivery of oligopeptides and oligonucleotides. A 16‐amino acid‐long peptide fragment, called penetratin, is
Membrane translocation of glutaric acid and its derivatives
✍ Scribed by C. Mühlhausen; B. C. Burckhardt; Y. Hagos; G. Burckhardt; B. Keyser; Z. Lukacs; K. Ullrich; T. Braulke
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 294 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0141-8955
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## Abstract Michael addition of the corresponding anions derived from diphenylphosphine oxide, dialkylphosphites, and a cyclic phosphite to α‐methylene‐glutaric esters (**1**) afforded the title compounds (**2–6**). Double debenzylation of 2‐phosphono glutaric esters **4b** and **5a** by catalytic
A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.