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Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model

✍ Scribed by Kil-Jung Kim; Jae-Sun Choi; Insug Kang; Kyu-Won Kim; Chul-Ho Jeong; Joo-Won Jeong

Book ID
117963477
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
394 KB
Volume
54
Category
Article
ISSN
0742-3098

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Melatonin suppresses tumor angiogenesis
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Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion distances from the existing vascular supply increases, resulting in hypoxia in the cancer cells. Sustained expansion of a tumor mass requires new blood vessel formation to provide rapidly proliferating tumor cell