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Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

✍ Scribed by Shi-Young Park; Won-Jun Jang; Eui-Yeun Yi; Ji-Yeong Jang; Yunjin Jung; Joo-Won Jeong; Yung-Jin Kim

Book ID
111264728
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
390 KB
Volume
48
Category
Article
ISSN
0742-3098

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Melatonin suppresses tumor angiogenesis
Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia
✍ Shi-Young Park; Won-Jun Jang; Eui-Yeun Yi; Ji-Yeong Jang; Yunjin Jung; Joo-Won J 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion distances from the existing vascular supply increases, resulting in hypoxia in the cancer cells. Sustained expansion of a tumor mass requires new blood vessel formation to provide rapidly proliferating tumor cell