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Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)

✍ Scribed by Anna Leja-Szpak; Jolanta Jaworek; Piotr Pierzchalski; Russel J. Reiter

Book ID
111264772
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
348 KB
Volume
49
Category
Article
ISSN
0742-3098

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## Abstract Neurotensin (NT) stimulates protein kinase D1 (PKD1), extracellular signal regulated kinase (ERK), c‐Jun N‐terminal Kinase (JNK), and DNA synthesis in the human pancreatic adenocarcinoma cell line PANC‐1. To determine the effect of PKD1 overexpression on these biological responses, we g