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M1969 Induced Overexpression of Protein Kinase D1 Stimulates Mitogenic Signaling in Human Pancreatic Carcinoma PANC-1 Cells

✍ Scribed by Kisfalvi, Krisztina; Sinnett-Smith, James; Guha, Sushovan; Rozengurt, Enrique


Book ID
122379472
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
138
Category
Article
ISSN
0016-5085

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## Abstract Neurotensin (NT) stimulates protein kinase D1 (PKD1), extracellular signal regulated kinase (ERK), c‐Jun N‐terminal Kinase (JNK), and DNA synthesis in the human pancreatic adenocarcinoma cell line PANC‐1. To determine the effect of PKD1 overexpression on these biological responses, we g