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Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis

✍ Scribed by Peltonen, Karita ;Kiviharju, Taija M. ;Järvinen, Päivi M. ;Ra, Runar ;Laiho, Marikki

Book ID
111259916
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
217 KB
Volume
18
Category
Article
ISSN
0893-5785

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec