## Abstract The DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastoma‐ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__‐methyl‐__
Mechanisms underlying resistance to streptozotocin in Mer+ and Mer− human tumor lines
✍ Scribed by Robert J. Fram; Norman Robichaud
- Book ID
- 115781498
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 664 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0006-2952
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## Abstract To assess the possible role of the DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) in resistance of brain neoplasms to the clinically important chloroethylating agent 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), we quantitated MGMT activity, BCNU survival, and the