Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines

✍ Scribed by Efferth, T. ;L�hrke, H. ;Volm, M.

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 563 KB
• Volume: 18
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00300777

✦ Synopsis

The natural resistance to doxorubicin of 15 human renal carcinoma cell lines was analyzed and compared to proliferative activity and expression of P-glycoprotein. We found a significant negative correlation between proliferative activity and natural resistance to doxorubicin, as well as between proliferative activity and the expression of P-glycoprotein. A positive correlation between resistance and expression of P-glycoprotein was found.