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Mechanisms of resistance to topoisomerase I-targeting drugs

✍ Scribed by Rasheed, Zeshaan A; Rubin, Eric H


Book ID
110068020
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
235 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Twenty previously synthesized fused heterocyclic DNA‐topoisomerase II (Topo II)‐inhibiting compounds were investigated for their potential efficacy in various human cancer cell lines that were derived from different tumor entities. Moreover, different multidrug‐resistant variants of the