Enhancement of radiotherapy with DNA topoisomerase I-targeted drugs
β Scribed by Allan Y. Chen; Rachel Chou; Shyh-Jen Shih; Derick Lau; David Gandara
- Book ID
- 108110018
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 176 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1040-8428
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Twenty previously synthesized fused heterocyclic DNAβtopoisomerase II (Topo II)βinhibiting compounds were investigated for their potential efficacy in various human cancer cell lines that were derived from different tumor entities. Moreover, different multidrugβresistant variants of the
## Abstract Topotecan (TPT), a waterβsoluble derivative of camptothecin, is a potent antitumor poison of human DNA topoisomerase I (top1) that stabilizes the cleavage complex between the enzyme and DNA. The role of the recently discovered TPT affinity to DNA remains to be defined. The aim of this w