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Mechanisms of protein folding

✍ Scribed by Viara Grantcharova; Eric J Alm; David Baker; Arthur L Horwich


Book ID
114314364
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
367 KB
Volume
11
Category
Article
ISSN
0959-440X

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Mechanisms of protein folding
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Protein folding mechanisms and the multi
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An important idea that emerges from the energy landscape theory of protein folding is that subtle global features of the protein landscape can profoundly affect the apparent mechanism of folding. The relationship between various characteristic temperatures in the phase diagrams and landmarks in the

Mechanism of protein folding
✍ O. B. Ptitsyn; A. V. Finkelstein πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 597 KB

## Abstract The first stage of protein self‐organizationβ€”the formation of a fluctuating secondary structure in the unfolded protein chainβ€”is considered. The stereochemical theory is presented enabling one to calculate helix‐coil and β‐structure‐coil equilibrium constants. It is shown that the most

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✍ C. Robert Matthews; Mark R. Hurle πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 436 KB πŸ‘ 1 views

Mutagenesis makes it possible to examine the effect of amino acid replacements on the folding and stability of proteins. The evaluation of kinetic and equilibrium folding data using reaction coordinate diagrams allows one to determine the roles that single amino acids play in the folding mechanism.